Cytokines and Implications for Fertility Hydrolase in Human Lymphocytes: Role of Progesterone Up-Regulates Anandamide
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چکیده
منابع مشابه
Endocannabinoid Degradation and Human Fertility
Anandamide (AEA) impairs mouse pregnancy and embryo development. Here, we overview the role of AEA in sexual function, focusing on AEA degradation during human pregnancy. Human peripheral lymphocytes express the AEA-hydrolyzing enzyme fatty acid amide hydrolase (FAAH), which decreases in miscarrying women. FAAH is regulated by progesterone and Th1/Th2 cytokines, whereas the AEA transporter and ...
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BACKGROUND Marijuana, the most used recreational drug, has been shown to have adverse effects on human reproduction. Endogenous cannabinoids (also called endocannabinoids) bind to the same receptors as those of Δ(9)-tetrahydrocannabinol (THC), the psychoactive component of Cannabis sativa. The most extensively studied endocannabinoids are anandamide (N-arachidonoylethanolamine, AEA) and 2-arach...
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The levels of the endocannabinoids anandamide and 2-arachidonoylglycerol (2-AG) are under the negative control of leptin in the rodent hypothalamus. As leptin and endocannabinoids play opposite roles in the control of reproduction, we have investigated whether the impaired fertility typical of leptin-defective ob/ob mice is due, in part, to enhanced uterine endocannabinoid levels. We found that...
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